Publication Details:

Established in 2008

Journal or Publication Title:

Armenian Journal of Physics=Ֆիզիկայի հայկական հանդես

Date of publication:

2016

Volume:

9

Number:

2

ISSN:

1829-1171

Official URL:

Corporate Creators:

National University of Architecture and Construction of Armenia, Yerevan ; Department of Microwave Radiophysics and Telecommunication, Yerevan State University ; Yerevan State Engineering University, Dept. of Machine Science, Yerevan, Armenia ; Yerevan State University, Faculty of Physics

Coverage:

167-172

Abstract:

The binding of antitumor drug netropsin with natural and synthetic doublestranded nucleic acids was investigated. Nucleic acids were irradiated by non-thermal millimeter coherent electromagnetic waves with resonant (64.5 and 50.3 GHz) and nonresonant (48.3 GHz) frequencies of water structures. Studies demonstrate that absorption curves of the complexes and the character of change during titration process are the same for irradiated and non-irradiated DNAs. The results show that binding constant (K) of netropsin with irradiated DNAs changes: almost by one order for B-form DNA (extracted from calf thymus) and is tripled in case of A-form DNA (poly(A)poly(U)). The changes of enthalpy (ΔH) and entropy (ΔS) for binding process were calculated by Van’t Hoff analysis from the dependence of K on the temperature. As a result of irradiation with resonant frequencies, increase in absolute values of ΔH and ΔS takes place, while in case of nonresonant irradiation these values practically remain constant.

Date created:

2016-05-01

Format:

pdf

Identifier:

oai:arar.sci.am:23446

Location of original object:

ՀՀ ԳԱԱ Հիմնարար գիտական գրադարան