Publication Details:
Journal or Publication Title:
Հայաստանի կենսաբանական հանդես =Biological Journal of Armenia
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Volume:
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Title:
Gender-related differences of physical parameters of rat erythrocyte membranes
Other title:
Creator:
G. V. Sahakyan ; G. G. Artsruni ; G. A. Poghosyan
Contributor(s):
Պատ․ խմբ․՝ Մ․ Գ․ Թումանյան (1948) ; Գ․ Հ․ Բաբաջանյան (1949-1954) ; Հ․ Գ․ Բատիկյան (1954-1977) ; Գլխ․ խմբ․՝ Է․ Գ․ Աֆրիկյան (1978-2007) ; Է․ Ս․ Գևորգյան (2008-2023) ; Ա․ Ա․ Առաքելյան (2023-)
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Uncontrolled Keywords:
Саакян Г. В. ; Арцруни Г. Г. ; Погосян Г. А. ; Սահակյան Գ. Վ. ; Արծրունի Գ. Գ. ; Պողոսյան Գ. Ա. ; Gender-related differences ; erythrocyte ghost ; membrane structure
Coverage:
Abstract:
The gender-related differences of some biophysical parameters of rat erythrocyte ghosts are investigated by spectrophotometric method using the fluorescent probes ANS and pyrene. Data obtained show that the ghosts of male rat erythrocytes are more negative charged than females’ and the straight of the bounding of peripheral proteins with lipid bilayer for female erythrocytes is less then for males’. The viscosity of female erythrocyte ghosts is more, but the compactness of the packing of phospholipids in lipid bilayer is less then in males’, while the microviscosity of male erythrocyte ghosts is more then females’. These results testified that, in all probability, there are structural and functional gender-related differences in membrane level and these sex-related structural specificities of cell membranes can underlie the gender-related differences in pharmacokinetics and pharmacodinamics.
Place of publishing:
Երևան