Publication Details:
"ՀՀ ԳԱԱ Զեկույցներ" հանդեսը հիմնադրվել է 1944թ.: Լույս է տեսնում տարին 4 անգամ, 2026-ից՝ 2 անգամ։
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ՀՀ ԳԱԱ Զեկույցներ = Доклады НАН РА = Reports NAS RA
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Creator:
Kolesnikov, Andrey E. ; Goncharova, Karina D. ; Ananikov, Valentine P.
Contributor(s):
Պատ․ խմբ.՝ Վ. Հ․ Համբարձումյան (1944-1959) ; Մ․ Մ․ Ջրբաշյան (1960-1965) ; Ա․ Գ․ Նազարով (1966-1983) ; Պատ․ խմբ․ տեղակալ՝ Վ․ Հ․ Ղազարյան (1983-1986) ; Պատ․ խմբ․՝ Դ․ Մ․ Սեդրակյան (1987-1999) ; Գլխավոր խմբ․՝ Ս․ Ա․ Համբարձումյան (2000-2004) ; Վ․ Ս․ Զաքարյան (2005-2018) ; Ռ․ Մ․ Մարտիրոսյան (2018-2025) ; Ա․ Ս․ Սաղյան (2026-)
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Uncontrolled Keywords:
process toxicity ; tox-Profiles ; catalytic reactions ; green chemistry ; life cycle assessment ; green toxicology
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Abstract:
Green chemistry has transformed chemical innovation by introducing quantitative metrics. However, favorable values for these metrics do not automatically translate into ecological sustainability. A chemical process comprises a dynamic mixture of reagents, catalysts, solvents, intermediates, byproducts, residual feedstocks, and waste streams, each contributing to its overall toxicological footprint. This review argues that toxicity assessment should shift from a compound-centered perspective to a process-level evaluation that considers how toxicological burden is created, transformed, displaced, concentrated, diluted, or released throughout a process life cycle. We propose an ecology-by-design framework that integrates reaction inventories, toxicological endpoints, new approach methodologies, Life Cycle Assessment, USEtox characterization, safe-and-sustainable-by-design principles, and machine-learning-enabled data infrastructures. The ultimate objective is a chemical industry in which ecological performance is optimized alongside yield, selectivity, productivity, energy use, carbon footprint, and cost.
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Երևան
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ՀՀ ԳԱԱ Հիմնարար գիտական գրադարան